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Title
Radiance spectroscopy tool box for characterizing Au Nanoparticles in tissue mimicking phantoms as applied to prostate
Source
Journal of Cancer Science and Therapy
Date
2011
Author
Grabtchak, Gerge
;
Palmer, Tyler J.
;
Whelan, William M.
Genre
Journal Article
Abstract
Background: We have developed a new approach to map localized inclusions of gold nanoparticles in the Intralipid-1% liquid phantom. Our goal was to...
Volume
3
Issue
S1-008
DOI
10.4172/1948-5956.S1-008
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Title
Study of laser-induced thermoelastic deformation of native and coagulated ex-vivo bovine liver tissues for estimating their optical and thermomechanical properties
Source
Journal of Biomedical Optics
Date
2010
Author
Soroushian, Behrouz
;
Whelan, William M.
;
Kolios, Michael C.
Genre
Journal Article
Volume
15
Issue
6
Start Page
065002
DOI
10.1117/1.3517455
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Title
Study of laser-induced thermoelastic deformation of native and coagulated ex-vivobovine liver tissues for estimating their optical and thermomechanical properties
Source
Journal of Biomedical Optics
Date
2010
Author
Soroushiam, Behrouz
;
Whelan, William M
;
Kolios, Michael C
Genre
Journal Article
Volume
15
Issue
6
Start Page
065002
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Title
Optoacoustic imaging in a murine prostate cancer model
Date
2010
Author
Patterson, Michelle P.
;
Riley, Christopher B.
;
Kolius, Michael C. Whelan;William M.
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Title
Assessment of thermal coagulation in ex-vivotissues using Raman spectroscopy
Source
Journal of Biomedical Optics
Date
2010
Author
Rodrigues, Matthew
;
Weersink, Robert A.
;
Whelan, William M.
Genre
Journal Article
Volume
15
Issue
6
Start Page
068001
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Title
Interstitial point radiance spectroscopy of turbid media
Source
Journal of Applied Physics
Date
2009
Author
Chin, Lee C. L.
;
Lloyd, Brendan
;
Whelan, William M.
;
Vitkin, I. A.
Genre
Journal Article
Volume
105
Issue
10
Start Page
102025
DOI
10.1063/1.3116132
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Title
A calibration technique for frequency domain photothermoacoustics
Source
European Physical Journal-Special Topics
Date
2008
Author
Spirou, G. M.
;
Mandelis, A.
;
Vitkin, I. A.
;
Whelan, William M.
Genre
Journal Article
Abstract
Photoacoustic (or more precisely, photothermoacoustic) signals are generated by the absorption of photons, expressed as acoustic waves, and can be...
Volume
153
Start Page
491
DOI
10.1140/epjst/e2008-00492-6
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Title
Frequency domain photothermoacoustic signal amplitude dependence on the optical properties of water
Subtitle
turbid polyvinyl chloride-plastisol system
Source
Applied Optics
Date
2008
Author
Spirou, Gloria M.
;
Mandelis, Andreas
;
Vitkin, I. Alex
;
Whelan, William M.
Genre
Journal Article
Abstract
Photoacoustic (more precisely, photothermoacoustic) signals generated by the absorption of photons can be related to the incident laser fluence...
Volume
47
Issue
14
Start Page
2564
DOI
10.1364/ao.47.002564
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Title
Perturbative diffusion theory formalism for interpreting temporal light intensity changes during laser interstitial thermal therapy
Source
Physics in Medicine and Biology
Date
2007
Author
Chin, Lee C. L.
;
Whelan, William M.
;
Vitkin, I. Alex
Genre
Journal Article
Abstract
In an effort to understand dynamic optical changes during laser interstitial thermal therapy ( LITT), we utilize the perturbative solution of the...
Volume
52
Issue
6
Start Page
1659
DOI
10.1088/0031-9155/52/6/008
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Title
Determination of the optical properties of turbid media using relative interstitial radiance measurements
Subtitle
Monte Carlo study, experimental validation, and sensitivity analysis
Source
Journal of Biomedical Optics
Date
2007
Author
Chin, Lee C. L.
;
Worthington, Arthur E.
;
Whelan, William M.
;
Vitkin, I. Alex
Genre
Journal Article
Abstract
Interstitial quantification of the optical properties of tissue is important in biomedicine for both treatment planning of minimally invasive laser...
Volume
12
Issue
6
Start Page
064027
DOI
10.1117/1.2821406
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Title
Information content of point radiance measurements in turbid media
Subtitle
implications for interstitial optical property quantification
Source
Applied Optics
Date
2006
Author
Chin, L. C. L.
;
Whelan, William M.
;
Vitkin, I. A.
Genre
Journal Article
Abstract
Motivated by a recent report by Dickey et al. [Phys. Med. Biol. 46, 2359 (2001)], who demonstrated optical property retrieval by using relative...
Volume
45
Issue
9
Start Page
2101
DOI
10.1364/ao.45.002101
Full Text
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Title
Laser photothermoacoustic heterodyned lock-in depth profilometry in turbid tissue phantoms
Source
Physical Review E
Date
2005
Author
Fan, Y.
;
Mandelis, A.
;
Spirou, G.
;
Vitkin, I. A.
;
Whelan, William M.
Genre
Journal Article
Abstract
Frequency-domain correlation and spectral analysis photothermoacoustic (FD-PTA) imaging is a promising new technique, which is being developed to...
Volume
72
Issue
5
Start Page
051908
DOI
10.1103/PhysRevE.72.051908
Publication Status
NO_OBJ
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Title
Characterization of measurement artefacts in fluoroptic temperature sensors
Subtitle
implications for laser thermal therapy at 810 nm
Source
Lasers in Surgery and Medicine
Date
2005
Author
Davidson, S. R. H.
;
Vitkin, I. A.
;
Sherar, M. D.
;
Whelan, William M.
Genre
Journal Article
Abstract
Background and Objectives: Fluoroptic sensors are used to measure interstitial temperatures but their utility for monitoring laser interstitial...
Volume
36
Issue
4
Start Page
297
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Title
Optical and acoustic properties at 1064 nm of polyvinyl chloride-plastisol for use as a tissue phantom in biomedical optoacoustics
Source
Physics in Medicine and Biology
Date
2005
Author
Spirou, G. M.
;
Oraevsky, A. A.
;
Vitkin, I. A.
;
Whelan, William M.
Genre
Journal Article
Abstract
A novel optoacoustic phantom made of polyvinyl chloride-plastisol (PVCP) for optoacoustic studies is described. The optical and acoustic properties...
Volume
50
Issue
14
Start Page
N141
DOI
10.1088/0031-9155/50/14/N01
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Title
A novel strategy for monitoring laser thermal therapy based on changes in optothermal properties of heated tissues
Source
International Journal of Thermophysics
Date
2005
Author
Whelan, William M.
;
Davidson, S. R. H.
;
Chin, L. C. L.
;
Vitkin, I. A.
Genre
Journal Article
Abstract
Laser thermal therapy uses near-infrared optical energy to heat and thereby treat diseased tissues such as solid tumors. A method to monitor the...
Volume
26
Issue
1
Start Page
233
DOI
10.1007/s10765-005-2372-0
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Title
Radiance-based monitoring of the extent of tissue coagulation during laser interstitial thermal therapy
Source
Optics Letters
Date
2004
Author
Chin, L. C. L.
;
Wilson, B. C.
;
Whelan, William M.
;
Vitkin, I. A.
Genre
Journal Article
Abstract
Optical monitoring relates the dynamic changes in measured light intensity to the extent of treatment-induced coagulation that occurs during laser...
Volume
29
Issue
9
Start Page
959
DOI
10.1364/ol.29.000959
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Title
Optical method using fluence or radiance measurements to monitor thermal therapy
Source
Review of Scientific Instruments
Date
2003
Author
Chin, L.
;
Pop, M.
;
Whelan, William M.
;
Sherar, M.
;
Vitkin, A.
Genre
Journal Article
Abstract
We present data from a two-region (coagulated and native tissue) Monte Carlo simulation in spherical geometry to assess the feasibility of using...
Volume
74
Issue
1
Start Page
393
DOI
10.1063/1.1519681
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Title
Optical monitoring of interstitial thermal therapy
Source
Review of Scientific Instruments
Date
2003
Author
Chin, L. C.
;
Pop, M.
;
Whelan, W. M.
;
Sherar, M. D.
;
Vitkin, I. A.
Genre
Journal Article
Volume
74
Start Page
393
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Title
Models and measurements of light intensity changes during laser interstitial thermal therapy
Subtitle
implications for optical monitoring of the coagulation boundary location
Source
Physics in Medicine and Biology
Date
2003
Author
Chin, L. C. L.
;
Whelan, William M.
;
Vitkin, I. A.
Genre
Journal Article
Abstract
We have developed a multi-region spherical Monte Carlo (MC) model to simulate the dynamic changes in light intensity measured during laser...
Volume
48
Issue
4
Start Page
543
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Title
Laser thermal therapy
Subtitle
utility of interstitial fluence monitoring for locating optical sensors
Source
Physics in Medicine and Biology
Date
2001
Author
Whelan, William M.
;
Chun, P.
;
Chin, L. C. L.
;
Sherar, M. D.
;
Vitkin, I. A.
Genre
Journal Article
Abstract
Multipoint optical fluence measurements can potentially be used to detect coagulation-induced changes in optical propagation during interstitial...
Volume
46
Issue
4
Start Page
N91
DOI
10.1088/0305-4470/34/6/308
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