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Title: Berberis vulgaris/Picrorhiza kurroa
Subtitle: Extending the treatment window for reperfusion injury
Source: European Journal of Medicinal Plants
Date: 2015
Author: Saleh, M. C.; Connell, B. J.; Saleh, T. M.
Genre: Journal Article
Abstract: Aims:
The present study investigates the neuroprotective effects of Berberis vulgaris and Picrorhiza kurroa in a rodent model of cerebral ischemia...
Volume: 8
Issue: 3
Start Page: 128
DOI: 10.9734/EJMP/2015/18000
Publication Status: PUBLISHED



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Title: Increasing the biological stability profile of a new chemical entity, UPEI-104, and potential use as a neuroprotectant against reperfusion-injury
Source: Brain Sciences
Date: 2015
Author: Saleh, Tarek; Connell, Barry; Kucukkaya, Inan; Abd-El-Aziz, Alaa
Genre: Journal Article
Abstract: Previous work in our laboratory demonstrated the utility of synthetic combinations of two naturally occurring, biologically active compounds. In...
Volume: 5
Issue: 2
Start Page: 130
DOI: 10.3390/brainsci5020130
Publication Status: PUBLISHED




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Title: ELR-CXC chemokine antagonism is neuroprotective in a rat model of ischemic stroke
Source: Neuroscience Letters
Date: 2015
Author: Connell, B.J.; Gordon, J.R.; Saleh, T.M.
Genre: Journal Article
Volume: 606
Start Page: 117
DOI: 10.1016/j.neulet.2015.08.041




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Title: UPEI-300, A Conjugate Of Lipoic Acid And Edaravone, Mediates Neuroprotection In Ischemia/Reperfusion
Source: Neuroscience Letters
Date: 2014
Author: Connell, Barry J. ; Saleh, Monique C.; Kucukkaya, Inan ; Abd-El-Aziz, Alaa S. ; Khan, Bobby V. ; Saleh, Tarek M.
Genre: Journal Article
Abstract: Edaravone, an electron spin trapper with radical scavenging activity, has been shown to be effective in reducing infarct volume in humans following...
Volume: 561
Start Page: 151
DOI: 10.1016/j.neulet.2013.12.060



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Title: Co-administration of Resveratrol and Lipoic acid, or their synthetic combination, enhances neuroprotection in a rat model of ischemia/reperfusion
Source: PLoS ONE
Date: 2014
Author: Saleh, Monique C.; Connell, Barry J.; Rajagopal, Desikan; Khan, Bobby V.; Abd-El-Aziz, Alaa S.; Kucukkaya, Inan; Saleh, Tarek M.
Genre: Journal Article
Abstract: The present study demonstrates the benefits of combinatorial antioxidant therapy in the treatment of ischemic stroke. Male Sprague-Dawley rats were...
Volume: 9
Issue: 1
Start Page: e87865
DOI: 10.1371/journal.pone.0087865
Publication Status: PUBLISHED




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Title: Apocynin-lipoic acid conjugates and uses thereof cross-reference to related applications
Date: 2013-05-23
Other Author(s): University of Prince Edward Island
Genre: Patent
Abstract: The present application relates to novel apocynin-lopioc acid covalent conjugates, compositions comprising these compounds and their use, in...




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Title: Apocynin-Lipoic Acid conjugates and uses therof cross-reference to related applications
Date: 2013
Genre: Patent
Abstract: The present application relates to novel apocynin-lipoic acid covalent conjugates, compositions comprising these compounds and their use, in...




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Title: Resveratrol induced neuroprotection is mediated via both estrogen receptor subtypes, Erα and Erβ
Source: Neuroscience Letters
Date: 2013
Author: Saleh, Monique C. ; Connell, Barry J. ; Saleh, Tarek M.
Genre: Journal Article
Abstract: Resveratrol, a dietary polyphenol with antioxidant and anti-inflammatory activity, has been shown to provide neuroprotection in models of ischemia....
Volume: 548
Start Page: 217
DOI: 10.1016/j.neulet.2013.05.057




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Title: Apocynin-Lipoic acid conjugates and uses thereof cross-reference to related applications
Date: 2013
Other Author(s): University of Prince Edward Island
Genre: Patent
Abstract: The present application relates to novel apocynin-lopioc acid covalent conjugates, compositions comprising these compounds and their use, in...




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Title: Animal stroke model
Date: 2012-12-20
Other Author(s): University Of Prince Edward Island
Genre: Patent
Abstract: An animal stroke model is provided. The model is useful in the study of brain ischemia and/or reperfusron injury and in identification and testing...



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Title: Novel neurovascular protective agents
Subtitle: Effects of INV-155, INV-157, INV-159, and INV-161 versus Lipoic Acid and Captopril in a rat stroke model
Source: Cardiology Research and Practice
Date: 2012
Author: Connell, Barry J.; Khan, Bobby V.; Rajagopal, Desikan; Saleh, Tarek M.
Genre: Journal Article
Abstract: Background. Lipoic acid (LA), which has significant antioxidant properties, may also function as a potent neuroprotectant. The synthetic compounds...
Volume: 2012
DOI: 10.1155/2012/319230
Publication Status: PUBLISHED




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Title: UPEI-100, a conjugate of lipoic acid and apocynin, mediates neuroprotection in a rat model of ischemia/reperfusion
Source: American Journal of Physiology-Regulatory Integrative and Comparative Physiology
Date: 2012
Author: Connell, B. J.; Saleh, M. C.; Khan, B. V.; Rajagopal, D.; Saleh, T. M.
Genre: Journal Article
Abstract: Previous work in our laboratory has provided evidence that preadministration of apocynin and lipoic acid at subthreshold levels for neuroprotection...
Volume: 302
Issue: 7
Start Page: R886
DOI: 10.1152/ajpregu.00644.2011




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Title: Guanosine protects against reperfusion injury in rat brain after ischemic stroke
Source: Journal of Neuroscience Research
Date: 2012
Author: Connell, Barry J.; Di Iorio, Patrizia ; Sayeed, Iqbal; Ballerini, Patrizia ; Saleh, Monique C.; Giuliani, Patricia ; Saleh, Tarek M.; Rathbone, Michel P. ; Su, Caixin
Genre: Journal Article
Abstract: After ischemic stroke, early thrombolytic therapy to reestablish tissue perfusion improves outcome but triggers a cascade of deleterious cellular...
Volume: 91
Issue: 2
Start Page: 262
DOI: 10.1002/jnr.23156
Publication Status: PUBLISHED




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Title: Apocynin may limit total cell death following cerebral ischemia and reperfusion by enhancing apoptosis
Source: Food and Chemical Toxicology
Date: 2011
Author: Connell, B. J.; Saleh, M.; Khan, B. V.; Saleh, T. M.
Genre: Journal Article
Abstract: The present study was designed to determine a dose-response relationship between apocynin and infarct volume as well as to provide a possible...
Volume: 49
Issue: 12
Start Page: 3063
DOI: 10.1016/j.fct.2011.09.010




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Title: Role of estrogen in central nuclei mediating stroke-induced changes in autonomic tone
Source: Journal of Stroke and Cerebrovascular Diseases
Date: 2003
Author: Saleh, Tarek M.; Cribb, Alastair E.; Connell, Barry J.
Genre: Journal Article
Abstract: The current investigation examined the role of estrogen in central autonomic regulatory nuclei on the autonomic dysfunction resulting from middle...
Volume: 12
Issue: 4
Start Page: 182
DOI: org/10.1016/S1052-3057(03)00080-6




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Title: Quantitative electron microscopy of the liver SER from rats fed PCB 126.
Source: FASEB Journal
Date: 1999
Author: Connell, B. J.; Singh, A.
Genre: Conference Abstract
Volume: 13
Issue: 4
Start Page: A345




Bookmarks:

Title: PCB congener 126-induced ultrastructural alterations in the rat liver
Subtitle: a stereological study
Source: Toxicology
Date: 1999
Author: Connell, B. J.; Singh, A.; Chu, I.
Genre: Journal Article
Abstract: Hepatocyte cytoplasmic alterations were morphometrically determined in male and female Sprague-Dawley rats fed PCB congener 126 (3,3',4,4',5...
Volume: 136
Issue: 2-3
Start Page: 107
DOI: 10.1016/s0300-483x(99)00062-1




Bookmarks:

Title: Interaction of PCB congeners and 2,3,7,8-TCDD in the rat liver
Subtitle: an electron microscope study
Source: Journal of Submicroscopic Cytology and Pathology
Date: 1998
Author: Connell, B. J.; Singh, A.; Chu, I.
Genre: Journal Article
Abstract: Polyhalogenated aromatic compounds such as polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins continue to be environmental...
Volume: 30
Issue: 1
Start Page: 157

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