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(1 - 18 of 18)
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Title
Berberis vulgaris/Picrorhiza kurroa
Subtitle
Extending the treatment window for reperfusion injury
Source
European Journal of Medicinal Plants
Date
2015
Author
Saleh, M. C.
;
Connell, B. J.
;
Saleh, T. M.
Genre
Journal Article
Abstract
Aims:
The present study investigates the neuroprotective effects of Berberis vulgaris and Picrorhiza kurroa in a rodent model of cerebral ischemia...
Volume
8
Issue
3
Start Page
128
DOI
10.9734/EJMP/2015/18000
Publication Status
PUBLISHED
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Title
Increasing the biological stability profile of a new chemical entity, UPEI-104, and potential use as a neuroprotectant against reperfusion-injury
Source
Brain Sciences
Date
2015
Author
Saleh, Tarek
;
Connell, Barry
;
Kucukkaya, Inan
;
Abd-El-Aziz, Alaa
Genre
Journal Article
Abstract
Previous work in our laboratory demonstrated the utility of synthetic combinations of two naturally occurring, biologically active compounds. In...
Volume
5
Issue
2
Start Page
130
DOI
10.3390/brainsci5020130
Publication Status
PUBLISHED
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Title
ELR-CXC chemokine antagonism is neuroprotective in a rat model of ischemic stroke
Source
Neuroscience Letters
Date
2015
Author
Connell, B.J.
;
Gordon, J.R.
;
Saleh, T.M.
Genre
Journal Article
Volume
606
Start Page
117
DOI
10.1016/j.neulet.2015.08.041
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Title
UPEI-300, A Conjugate Of Lipoic Acid And Edaravone, Mediates Neuroprotection In Ischemia/Reperfusion
Source
Neuroscience Letters
Date
2014
Author
Connell, Barry J.
;
Saleh, Monique C.
;
Kucukkaya, Inan
;
Abd-El-Aziz, Alaa S.
;
Khan, Bobby V.
;
Saleh, Tarek M.
Genre
Journal Article
Abstract
Edaravone, an electron spin trapper with radical scavenging activity, has been shown to be effective in reducing infarct volume in humans following...
Volume
561
Start Page
151
DOI
10.1016/j.neulet.2013.12.060
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Title
Co-administration of Resveratrol and Lipoic acid, or their synthetic combination, enhances neuroprotection in a rat model of ischemia/reperfusion
Source
PLoS ONE
Date
2014
Author
Saleh, Monique C.
;
Connell, Barry J.
;
Rajagopal, Desikan
;
Khan, Bobby V.
;
Abd-El-Aziz, Alaa S.
;
Kucukkaya, Inan
;
Saleh, Tarek M.
Genre
Journal Article
Abstract
The present study demonstrates the benefits of combinatorial antioxidant therapy in the treatment of ischemic stroke. Male Sprague-Dawley rats were...
Volume
9
Issue
1
Start Page
e87865
DOI
10.1371/journal.pone.0087865
Publication Status
PUBLISHED
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Title
Apocynin-lipoic acid conjugates and uses thereof cross-reference to related applications
Date
2013-05-23
Other Author(s)
University of Prince Edward Island
Genre
Patent
Abstract
The present application relates to novel apocynin-lopioc acid covalent conjugates, compositions comprising these compounds and their use, in...
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Title
Apocynin-Lipoic Acid conjugates and uses therof cross-reference to related applications
Date
2013
Genre
Patent
Abstract
The present application relates to novel apocynin-lipoic acid covalent conjugates, compositions comprising these compounds and their use, in...
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Title
Resveratrol induced neuroprotection is mediated via both estrogen receptor subtypes, Erα and Erβ
Source
Neuroscience Letters
Date
2013
Author
Saleh, Monique C.
;
Connell, Barry J.
;
Saleh, Tarek M.
Genre
Journal Article
Abstract
Resveratrol, a dietary polyphenol with antioxidant and anti-inflammatory activity, has been shown to provide neuroprotection in models of ischemia....
Volume
548
Start Page
217
DOI
10.1016/j.neulet.2013.05.057
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Title
Apocynin-Lipoic acid conjugates and uses thereof cross-reference to related applications
Date
2013
Other Author(s)
University of Prince Edward Island
Genre
Patent
Abstract
The present application relates to novel apocynin-lopioc acid covalent conjugates, compositions comprising these compounds and their use, in...
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Title
Animal stroke model
Date
2012-12-20
Other Author(s)
University Of Prince Edward Island
Genre
Patent
Abstract
An animal stroke model is provided. The model is useful in the study of brain ischemia and/or reperfusron injury and in identification and testing...
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Title
Novel neurovascular protective agents
Subtitle
Effects of INV-155, INV-157, INV-159, and INV-161 versus Lipoic Acid and Captopril in a rat stroke model
Source
Cardiology Research and Practice
Date
2012
Author
Connell, Barry J.
;
Khan, Bobby V.
;
Rajagopal, Desikan
;
Saleh, Tarek M.
Genre
Journal Article
Abstract
Background. Lipoic acid (LA), which has significant antioxidant properties, may also function as a potent neuroprotectant. The synthetic compounds...
Volume
2012
DOI
10.1155/2012/319230
Publication Status
PUBLISHED
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Title
UPEI-100, a conjugate of lipoic acid and apocynin, mediates neuroprotection in a rat model of ischemia/reperfusion
Source
American Journal of Physiology-Regulatory Integrative and Comparative Physiology
Date
2012
Author
Connell, B. J.
;
Saleh, M. C.
;
Khan, B. V.
;
Rajagopal, D.
;
Saleh, T. M.
Genre
Journal Article
Abstract
Previous work in our laboratory has provided evidence that preadministration of apocynin and lipoic acid at subthreshold levels for neuroprotection...
Volume
302
Issue
7
Start Page
R886
DOI
10.​1152/​ajpregu.​00644.​2011
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Title
Guanosine protects against reperfusion injury in rat brain after ischemic stroke
Source
Journal of Neuroscience Research
Date
2012
Author
Connell, Barry J.
;
Di Iorio, Patrizia
;
Sayeed, Iqbal
;
Ballerini, Patrizia
;
Saleh, Monique C.
;
Giuliani, Patricia
;
Saleh, Tarek M.
;
Rathbone, Michel P.
;
Su, Caixin
Genre
Journal Article
Abstract
After ischemic stroke, early thrombolytic therapy to reestablish tissue perfusion improves outcome but triggers a cascade of deleterious cellular...
Volume
91
Issue
2
Start Page
262
DOI
10.1002/jnr.23156
Publication Status
PUBLISHED
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Title
Apocynin may limit total cell death following cerebral ischemia and reperfusion by enhancing apoptosis
Source
Food and Chemical Toxicology
Date
2011
Author
Connell, B. J.
;
Saleh, M.
;
Khan, B. V.
;
Saleh, T. M.
Genre
Journal Article
Abstract
The present study was designed to determine a dose-response relationship between apocynin and infarct volume as well as to provide a possible...
Volume
49
Issue
12
Start Page
3063
DOI
10.1016/j.fct.2011.09.010
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Title
Role of estrogen in central nuclei mediating stroke-induced changes in autonomic tone
Source
Journal of Stroke and Cerebrovascular Diseases
Date
2003
Author
Saleh, Tarek M.
;
Cribb, Alastair E.
;
Connell, Barry J.
Genre
Journal Article
Abstract
The current investigation examined the role of estrogen in central autonomic regulatory nuclei on the autonomic dysfunction resulting from middle...
Volume
12
Issue
4
Start Page
182
DOI
org/10.1016/S1052-3057(03)00080-6
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Title
Quantitative electron microscopy of the liver SER from rats fed PCB 126.
Source
FASEB Journal
Date
1999
Author
Connell, B. J.
;
Singh, A.
Genre
Conference Abstract
Volume
13
Issue
4
Start Page
A345
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Title
PCB congener 126-induced ultrastructural alterations in the rat liver
Subtitle
a stereological study
Source
Toxicology
Date
1999
Author
Connell, B. J.
;
Singh, A.
;
Chu, I.
Genre
Journal Article
Abstract
Hepatocyte cytoplasmic alterations were morphometrically determined in male and female Sprague-Dawley rats fed PCB congener 126 (3,3',4,4',5...
Volume
136
Issue
2-3
Start Page
107
DOI
10.1016/s0300-483x(99)00062-1
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Title
Interaction of PCB congeners and 2,3,7,8-TCDD in the rat liver
Subtitle
an electron microscope study
Source
Journal of Submicroscopic Cytology and Pathology
Date
1998
Author
Connell, B. J.
;
Singh, A.
;
Chu, I.
Genre
Journal Article
Abstract
Polyhalogenated aromatic compounds such as polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins continue to be environmental...
Volume
30
Issue
1
Start Page
157