Peptide conjugated chemotherapeutics for breast cancer treatment
Murad Bhayo, Adam Rasouli, Rahimeh Ahmed, Marya
2021 UPEI Graduate Studies and Research Conference
Abstract
2021
Chemistry
The treatment of cancer disorders often implies the use of chemotherapy, radiation, and surgery. Unfortunately, high toxicity, low selectivity, and a wide range of undesired side-effects are associated with them. Hence, there is an urgent need to achieve an innovative treatment that can improve the efficacy of current therapeutic agents. Immunotherapy, where the patient’s immune system is exploited to eliminate tumor cells, has become one of the most prominent cancer treatment approaches in the Show moreThe treatment of cancer disorders often implies the use of chemotherapy, radiation, and surgery. Unfortunately, high toxicity, low selectivity, and a wide range of undesired side-effects are associated with them. Hence, there is an urgent need to achieve an innovative treatment that can improve the efficacy of current therapeutic agents. Immunotherapy, where the patient’s immune system is exploited to eliminate tumor cells, has become one of the most prominent cancer treatment approaches in the last decade. Cancer immunotherapy can stimulate and/or promote the immune system in the body to indirectly attack and kill tumor cells, with the goal of improving anti-tumor immunity while reducing off-target effects. However, establishing versatile strategies with high biosafety and the capability for efficient modulation of immune responses remains challenging. Peptide-based materials hold great promise as immunomodulatory agents for the treatment of cancer. This study is aimed to synthesize a library of immunomodulatory peptides conjugated chemotherapeutics and to evaluate their anticancer efficacies. Show less
