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Title: Synaptic dysfunction in human neurons with autism-associated deletions in PTCHD1-AS
Source: Biological Psychiatry
Date: 2020
Author: Ross, P. Joel; Zhang, Wen-Bo; Mok, Rebecca S.F.; Zaslavsky, Kirill; Deneault, Eric; D’Abate, Lia; Rodrigues, Deivid C.; Yuen, Ryan K.C.; Faheem, Muhammad; Mufteev, Marat; Piekna, Alina; Wei, Wei; Pasceri, Peter; Landa, Rebecca J.; Nagy, Andras; Varga, Balazs; Salter, Michael W.; Scherer, Stephen W.; Ellis, James
Genre: Journal Article
Abstract: Background The Xp22.11 locus that encompasses PTCHD1, DDX53, and the long noncoding RNA PTCHD1-AS is frequently disrupted in male subjects with...
Volume: 87
Issue: 2
Start Page: 139
DOI: 10.1016/j.biopsych.2019.07.014
Publication Status: PUBLISHED



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Title: Shifts in ribosome engagement impact key gene sets in neurodevelopment and ubiquitination in Rett Syndrome
Source: Cell Reports
Date: 2020
Author: Rodrigues, Deivid C.; Mufteev, Marat; Weatheritt, Robert J.; Djuric, Ugljesa; Ha, Kevin C.H.; Ross, P. Joel; Wei, Wei; Piekna, Alina; Sartori, Maria A.; Byres, Loryn; Mok, Rebecca S.F.; Zaslavsky, Kirill; Pasceri, Peter; Diamandis, Phedias; Morris, Quaid; Blencowe, Benjamin J.; Ellis, James
Genre: Journal Article
Abstract: Regulation of translation during human development is poorly understood, and its dysregulation is associated with Rett syndrome (RTT). To discover...
Volume: 30
Issue: 12
Start Page: 4179
DOI: 10.1016/j.celrep.2020.02.107
Publication Status: PUBLISHED



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Title: Modeling neuronal consequences of autism-associated gene regulatory variants with human induced pluripotent stem cells
Source: Molecular Autism
Date: 2020
Author: Ross, P. Joel; Mok, Rebecca S. F.; Smith, Brandon S.; Rodrigues, Deivid C.; Mufteev, Marat; Scherer, Stephen W.; Ellis, James
Genre: Journal Article
Abstract: Genetic factors contribute to the development of autism spectrum disorder (ASD), and although non-protein-coding regions of the genome are being...
Volume: 11
Issue: 1
DOI: 10.1186/s13229-020-00333-6
Publication Status: PUBLISHED



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Title: Control of tong-term synaptic potentiation and learning by alternative splicing of the NMDA receptor subunit GluN1
Source: Cell Reports
Date: 2019
Author: Sengar, Ameet S.; Li, Hongbin; Zhang, Wenbo; Leung, Celeste; Ramani, Arun K.; Saw, Ner Mu; Wang, Yongqian; Tu, YuShan; Ross, P. Joel; Scherer, Stephen W.; Ellis, James; Brudno, Michael; Jia, Zhengping; Salter, Michael W.
Genre: Journal Article
Abstract: NMDA receptors (NMDARs) are critical for physiological synaptic plasticity, learning, and memory and for pathological plasticity and neuronal death...
Volume: 29
Issue: 13
Start Page: 4285
DOI: 10.1016/j.celrep.2019.11.087
Publication Status: PUBLISHED




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Title: SHANK2 mutations associated with autism spectrum disorder cause hyperconnectivity of human neurons
Source: Nature Neuroscience
Date: 2019
Author: Zaslavsky, Kirill; Zhang, Wen-Bo; McCready, Fraser P.; Rodrigues, Deivid C.; Deneault, Eric; Loo, Caitlin; Zhao, Melody; Ross, P. Joel; El Hajjar, Joelle; Romm, Asli; Thompson, Tadeo; Piekna, Alina; Wei, Wei; Wang, Zhuozhi; Khattak, Shahryar; Mufteev, Marat; Pasceri, Peter; Scherer, Stephen W.; Salter, Michael W.; Ellis, James
Genre: Journal Article
Abstract: Heterozygous loss-of-function mutations in SHANK2 are associated with autism spectrum disorder (ASD). We generated cortical neurons from induced...
Volume: 22
Issue: 4
Start Page: 556
DOI: 10.1038/s41593-019-0365-8



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Title: Complete disruption of autism-susceptibility genes by gene editing predominantly reduces functional connectivity of isogenic human neurons
Source: Stem Cell Reports
Date: 2018
Author: Deneault, Eric; White, Sean H.; Rodrigues, Deivid C.; Ross, P. Joel; Faheem, Muhammad; Zaslavsky, Kirill; Wang, Zhuozhi; Alexandrova, Roumiana; Pellecchia, Giovanna; Wei, Wei; Piekna, Alina; Kaur, Gaganjot; Howe, Jennifer L.; Kwan, Vickie; Thiruvahindrapuram, Bhooma; Walker, Susan; Lionel, Anath C.; Pasceri, Peter; Merico, Daniele; Yuen, Ryan K.C.; Singh, Karun K.; Ellis, James; Scherer, Stephen W.
Genre: Journal Article
Abstract: Autism spectrum disorder (ASD) is phenotypically and genetically heterogeneous. We present a CRISPR gene editing strategy to insert a protein tag...
Volume: 11
Issue: 5
Start Page: 1211
DOI: 10.1016/j.stemcr.2018.10.003
Publication Status: PUBLISHED



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Title: MECP2 Is post-transcriptionally regulated during human neurodevelopment by combinatorial action of RNA-binding proteins and miRNAs
Source: Cell Reports
Date: 2016
Author: Rodrigues, Deivid C.; Kim, Dae-Sung; Yang, Guang; Zaslavsky, Kirill; Ha, Kevin C.H.; Mok, Rebecca S.F.; Ross, P. Joel; Zhao, Melody; Piekna, Alina; Wei, Wei; Blencowe, Benjamin J.; Morris, Quaid; Ellis, James
Genre: Journal Article
Volume: 17
Issue: 3
Start Page: 720
DOI: 10.1016/j.celrep.2016.09.049
Publication Status: PUBLISHED



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Title: Fyn Kinase regulates GluN2B subunit-dominant NMDA receptors in human induced pluripotent stem cell-derived neurons
Source: Scientific Reports
Date: 2016
Author: Zhang, Wen-Bo; Ross, P. Joel; Tu, YuShan; Wang, Yongqian; Beggs, Simon; Sengar, Ameet S.; Ellis, James; Salter, Michael W.
Genre: Journal Article
Volume: 6
Issue: 1
Start Page: 23837
DOI: 10.1038/srep23837
Publication Status: PUBLISHED



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Title: Human induced pluripotent stem cell derived neurons as a model for Williams-Beuren syndrome
Source: Molecular Brain
Date: 2015
Author: Khattak, Shahryar; Brimble, Elise; Zhang, Wenbo; Zaslavsky, Kirill; Strong, Emma; Ross, P. Joel; Hendry, Jason; Mital, Seema; Salter, Michael W.; Osborne, Lucy R.; Ellis, James
Genre: Journal Article
Volume: 8
Issue: 1
Start Page: 77
DOI: 10.1186/s13041-015-0168-0
Publication Status: PUBLISHED



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Title: MECP2e1 isoform mutation affects the form and function of neurons derived from Rett syndrome patient iPS cells
Source: Neurobiology of Disease
Date: 2015
Author: Djuric, Ugljesa; Cheung, Aaron Y.L.; Zhang, Wenbo; Mok, Rebecca S.; Lai, Wesley; Piekna, Alina; Hendry, Jason A.; Ross, P. Joel; Pasceri, Peter; Kim, Dae-Sung; Salter, Michael W.; Ellis, James
Genre: Journal Article
Volume: 76
Start Page: 37
DOI: 10.1016/j.nbd.2015.01.001
Publication Status: PUBLISHED



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Title: Optimizing neuronal differentiation from induced pluripotent stem cells to model ASD
Source: Frontiers in Cellular Neuroscience
Date: 2014
Author: Kim, Dae-Sung; Ross, P. Joel; Zaslavsky, Kirill; Ellis, James
Genre: Journal Article
Volume: 8
DOI: 10.3389/fncel.2014.00109
Publication Status: PUBLISHED




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Title: MBNL proteins repress ES-cell-specific alternative splicing and reprogramming
Source: Nature
Date: 2013
Author: Han, Hong; Irimia, Manuel; Ross, P. Joel; Sung, Hoon-Ki; Alipanahi, Babak; David, Laurent; Golipour, Azadeh; Gabut, Mathieu; Michael, Iacovos P.; Nachman, Emil N.; Wang, Eric; Trcka, Dan; Thompson, Tadeo; O’Hanlon, Dave; Slobodeniuc, Valentina; Barbosa-Morais, Nuno L.; Burge, Christopher B.; Moffat, Jason; Frey, Brendan J.; Nagy, Andras; Ellis, James; Wrana, Jeffrey L.; Blencowe, Benjamin J.
Genre: Journal Article
Volume: 498
Issue: 7453
Start Page: 241
DOI: 10.1038/nature12270




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Title: MEF2 negatively regulates learning-induced structural plasticity and memory formation
Source: Nature Neuroscience
Date: 2012
Author: Cole, Christina J; Mercaldo, Valentina; Restivo, Leonardo; Yiu, Adelaide P; Sekeres, Melanie J; Han, Jin-Hee; Vetere, Gisella; Pekar, Tetyana; Ross, P Joel; Neve, Rachael L; Frankland, Paul W; Josselyn, Sheena A
Genre: Journal Article
Volume: 15
Issue: 9
Start Page: 1255
DOI: 10.1038/nn.3189




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Title: Assembly of helper-dependent adenovirus DNA into chromatin promotes efficient gene expression
Source: Journal of Virology
Date: 2011
Author: Ross, P. J.; Kennedy, M. A.; Christou, C.; Risco Quiroz, M.; Poulin, K. L.; Parks, R. J.
Genre: Journal Article
Volume: 85
Issue: 8
Start Page: 3950
DOI: 10.1128/JVI.01787-10




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Title: Spine growth in the anterior cingulate cortex is necessary for the consolidation of contextual fear memory
Source: Proceedings of the National Academy of Sciences
Date: 2011
Author: Vetere, G.; Restivo, L.; Cole, C. J.; Ross, P. J.; Ammassari-Teule, M.; Josselyn, S. A.; Frankland, P. W.
Genre: Journal Article
Volume: 108
Issue: 20
Start Page: 8456
DOI: 10.1073/pnas.1016275108



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Title: Modeling complex neuropsychiatric disease with induced pluripotent stem cells
Source: F1000 Biology Reports
Date: 2010
Author: Ellis, James P.; Ross, P. Joel
Genre: Journal Article
Volume: 2
DOI: 10.3410/B2-84
Publication Status: PUBLISHED




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Title: Host cell detection of noncoding stuffer DNA contained in helper-dependent adenovirus vectors leads to epigenetic repression of transgene expression
Source: Journal of Virology
Date: 2009
Author: Ross, P. J.; Kennedy, M. A.; Parks, R. J.
Genre: Journal Article
Volume: 83
Issue: 17
Start Page: 8409
DOI: 10.1128/JVI.00796-09




Bookmarks:

Title: Construction and characterization of adenovirus vectors
Source: Cold Spring Harbor Protocols
Date: 2009
Author: Ross, P. J.; Parks, R. J.
Genre: Journal Article
Abstract: Genetically modified adenoviruses (Ads) make attractive vectors for the delivery of exogenous DNA to mammalian cells for basic science and gene...
Volume: 2009
Issue: 5
DOI: 10.1101/pdb.prot5011




Bookmarks:

Title: The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
Source: Nature
Date: 2008
Author: Muruve, Daniel A.; Pétrilli, Virginie; Zaiss, Anne K.; White, Lindsay R.; Clark, Sharon A.; Ross, P. Joel; Parks, Robin J.; Tschopp, Jurg
Genre: Journal Article
Volume: 452
Issue: 7183
Start Page: 103
DOI: 10.1038/nature06664




Bookmarks:

Title: Helper-dependent adenovirus vectors elicit intact innate but attenuated adaptive host immune responses in vivo
Source: Journal of Virology
Date: 2004
Author: Muruve, Daniel A.; Cotter, Matthew J.; Zaiss, Anne K.; White, Lindsay R.; Liu, Qiang; Chan, Trevor; Clark, Sharon A.; Ross, P. Joel; Meulenbroek, Robert A.; Maelandsmo, Gunhild M.; Parks, Robin J.
Genre: Journal Article
Abstract: Helper-dependent adenovirus (HD-Ad) vectors with all adenoviral genes deleted mediate very long-term expression of therapeutic transgenes in a...
Volume: 78
Issue: 11
Start Page: 5966
DOI: 10.1128/JVI.78.11.5966-5972.2004

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